The Department of Energy's Advanced Research Projects Agency–Energy (ARPA-E) has awarded a total of $36 million for 11 projects to develop technologies that will limit the amount of waste produced from advanced reactors and will support sustainable domestic fuel stocks. The projects include research into the facilities and systems required to reprocess, recycle, and dispose of spent fuel generated through diverse advanced reactor fuel cycles.

A statistically predicted tendency for neutrons produced inside fission reactors to form in clusters can cause asymmetrical energy production that is counterbalanced, at least in part, by the spontaneous fission of radioactive material in the reactor.